The overall goal of the SEMI-NUC project was to assess the feasibility of establishing a united cohort of residents around the Semipalatinsk site.

The main objectives of the feasibility study included:

  • developing and testing mechanisms for the identification of cohort members in the two cohorts
  • identification and testing of data-linkage mechanisms
  • determination of the outcomes to be studied in the future (cancer and non-cancer diseases)
  • setting up and testing procedures for follow-up
  • identification of case-ascertainment mechanisms and sources, depending on the outcome
  • characterization and validation of the dose assessment methods used in the two cohorts, (sources of exposure pathways, various dose calculation methods)
  • investigation of the feasibility of collecting data on confounding factors (e.g. life-style factors)
  • assessing the availability of biological samples, including characterization of archived biological samples and their potential use in the future

The main conclusion of the project was that a prospective cohort study to examine various long-term health effects from chronic exposure to low and moderate doses of ionizing radiation is feasible.